NFL Week 16 Odds & Betting Lines (Spread, Total, Moneyline)

Companies featured on this page may be our partners that compensate us if you sign up for one through our links. This doesn't affect our ratings or opinions in any way. Learn more here. Must be 21+. Gambling Problem? Call 1-800-GAMBLER.

Use our free NFL Week 16 odds comparison tool below to shop for the best spread, total, and moneyline odds and lines at legal online sportsbooks in the U.S. Filter by state and sportsbooks to see only the ones you want.

Once you find the best odds or lines for Week 16, simply click the tile to sign up (if you aren't already a user) and place your bet.

Scroll to the right to compare current NFL odds & lines at sportsbooks >>

Spread
Moneyline
Total
Default

Dave Rathmanner

Dave Rathmanner is the Founder & CEO of Odds Assist. After struggling to find helpful sports betting resources and honest reviews when he first started betting, he decided to create the site he always wished he had. Dave has been betting on sports since NJ legalized it in 2018 and regularly analyzes sportsbooks to find the best options for bettors. Aside from creating new content for OA readers, Dave is also passionate about researching betting markets, creating models, and developing profitable betting strategies.