NFL Week 10 Picks – Sunday Best Bets

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We had an up-and-down week in Week 10, going 3-3-1 on our Sunday Best Bets. Let's see if we can get back to profitability in Week 10 with some more spread and total picks from our team of experts.

Below you'll find our picks for the best bets to make on Sunday of Week 10 of the NFL season. Remember, you can always compare NFL lines and odds by sportsbooks here.

Sunday Best Bets Season Record: 45-29-2 (+17.05 units)

Best Sunday Bets – NFL Week 10 Picks

Arizona Cardinals @ Los Angeles Rams OVER 38 – 4:25 pm

Rob O'Connor
Rob O'Connor

Rob O’Connor is a veteran sports handicapper. He broke into the industry in 2002 and has continued to provide high quality sports handicapping advice ever since.

Two NFC West rivals square off Sunday when the Rams host the Cardinals.

The Rams may be forced to go with a backup QB in this one as starter Matthew Stafford entered concussion protocol earlier this week and is questionable at best to play.

This may not be a bad thing for the Rams, they have struggled with Stafford behind center.

WR Cooper Kupp has had a lot of success against the Cardinals in recent meetings and that should continue in this one as the Cardinals have the 8th worst defense against the pass in the league. They have allowed 16 passing touchdowns already on the season tied for 3rd most in the league.

The Cardinals are allowing the 2nd most points in the league at 26.8 per game, so even the struggling Rams offense should find some points in this one.

On the other side, the Rams are middle of the pack allowing 21.6 points per game.

While these teams have trended under in 6 of the last 10 games against each other, the totals were set much higher for those games than the total of 40 on Sunday. 7 of the last 10 between these two teams have seen at least 40 points scored. Clearly, there was an adjustment down for this one, but it has gone too far down in my opinion.

This game should easily make it into the 40s on Sunday, play the OVER.

Las Vegas Raiders –4 vs. Indianapolis Colts – 4:05 pm

Ernie Horn
Ernie Horn

Ernie Horn is a veteran newspaper writer with 25 years of experience. As a bettor, Ernie has exceeded 60% of his predictions over the past three years.

When Indianapolis travels to play the Las Vegas Raiders Sunday afternoon, the Colts may be wearing name tags for TV analyst turned NFL head coach Jeff Saturday.

In a shocking move, Indianapolis hired Saturday as interim coach on the same day they fired Frank Reich. Offensive woes were too much to take for the Colts’ front office as neither veteran Matt Ryan nor second-year QB Sam Ehlinger have been effective. Indianapolis owns the second-worst scoring offense in the NFL, a category Saturday is expected to address immediately.

The Raiders, meanwhile, will try to break a two-game losing streak in their first home game of November. Derek Carr helms an offense that moves the ball effectively through the air, averaging 244 yards per outing. Josh Jacobs is among the NFL’s league leaders in rushing, averaging 5.4 yards per rush with 743 yards and six rushing TDs.

Las Vegas will score at will against the middling Colts defense, and expect Indianapolis to continue their downward spiral with an ugly loss to the Raiders this week by up to two touchdowns.

Seahawks Moneyline @ Tampa Bay Buccaneers – 9:30 am

Kyler Wolff
Kyler Wolff

Kyler Wolff is a sports writer with a passion for football & statistical analysis. He uses his knowledge of the game and ability to break down stats to make the best picks.

The Buccaneers won an ugly game late against a beat-up and lethargic Rams team, that have been having an equally bad season. This win by no means should give anyone hope that they can turn it around and start beating red-hot teams like the Seahawks. This isn’t the same Bucs team from ‘21 or ‘20, and frankly, this is not the same Tom Brady either.

One good drive late in the Rams game doesn’t change the fact that Brady is 45 years old and out of sync with his receivers. They can’t rely solely on their defense alone, not against a Seahawks team that is lighting up the scoreboard at the moment.

The Seahawks have completely shattered expectations this season, and now seem to be a legit playoff contender. A large part of this success is due to the resurgence of one Geno Smith, who has been electrifying so far this season, throwing for 244 yards per game, 15 touchdowns, and only 4 picks, he’s also running the ball more, with 196 yards on the ground so far.

Add in star rookie RB Kenneth Walker III’s production, and you have a team that averages 26.8 points and 378 yards per game.

The wildcard in this game is going to be how well Seattle’s defense holds up against Brady and the Bucs' Defense. They have given up 24.4 points per game and nearly 385 yards per game.

It’s a defense made up of a rag-tag crew full of rookies and mid-level veterans, but with Pete Carroll’s leadership, they have actually been playing very well of late, only giving up 16.5 points per game over their last four games, compared to a whopping 30.8 over the first five.

This defense can absolutely handle the Tampa offense, this is an easy underdog pick.

Dallas Cowboys @ Green Bay Packers UNDER 44.5 – 4:25 pm

Rob O'Connor
Rob O'Connor

Rob O’Connor is a veteran sports handicapper. He broke into the industry in 2002 and has continued to provide high quality sports handicapping advice ever since.

The Dallas Cowboys travel to Green Bay to take on the Packers Sunday afternoon.

It will be cold for this one, with temperatures falling through the 30s during the game and wind chill making it feel in the 20s.

The Packers have been a disaster on offense this season averaging only 17.1 points per game, 6th worst in the league. Aaron Rodgers simply does not have a lot of weapons to work with.

It will not get any easier for the Packers against the Cowboys defense that is 3rd in the league allowing only 16.6 points per game.

The Packers also have a very solid defense, despite being middle of the pack in points allowed, they are 6th best in the league in yards allowed per game, giving up only 309.1 yards per contest.

The Cowboys have continued to show a very balanced approach on offense running the ball almost as much as they throw it and given the weather Sunday it would seem likely running the ball and keeping Aaron Rodgers off the field will be a big part of their game plan.

The Packers are 7th worst against the run and the Cowboys are 9th worst again the run this season, so the Packers should be looking to run the ball too.

Running, cold weather, and two good defenses are the perfect recipe for an UNDER play Sunday.

New Orleans Saints +1 @ Pittsburgh Steelers – 1 pm (Competing Picks)

Kyler Wolff
Kyler Wolff

Kyler Wolff is a sports writer with a passion for football & statistical analysis. He uses his knowledge of the game and ability to break down stats to make the best picks.

I wouldn’t necessarily describe the Saints right now as a particularly good team. Their defense is dealing with injuries, but even when healthy can’t seem to stop offenses not led by Derek Carr. They’ve given up 25 points or more in five of their last six games, and have struggled to keep up on offense.

With that being said, I think the Saints may be on the verge of a blowout win this weekend.

The Steelers are bad right now, their offense has been in shambles, led by a rookie QB who looks very much like a rookie QB at the moment, throwing eight picks so far this season compared to just two touchdowns.

Najee Harris has also struggled mightily early this season, going from 3.9 yards per carry and 70 yards per game last season to just 3.3 yards per carry and 45 yards per game. Nothing is going for the Steelers offensively.

Now let’s look at the other side of the ball.

The Steelers' defense has been nearly as bad as the offense, but at least they have the excuse of having to match up with overpowered offenses like the Bills, Dolphins, and Eagles recently.

Despite being clearly outmatched in those games, it is still abundantly clear that there is something wrong with defense, namely the lack of T.J. Watt (who will be back this week, but it will take a few weeks for him to be 100%). Other than T.J.’s absence, there have also been secondary problems, problems up front, and problems getting pressure. What I’m trying to say is that the only thing working on the Steelers' defense is Myles Jack.

The Saints (led by Andy Dalton, of all people) are in a great position to rip apart this struggling defense, and we don’t even need to worry about the Saints defense being lackluster and injured. The Steelers haven’t been able to put up any points this season (15 points per game so far for Pittsburgh).

The spread right now is +1 for the Saints, and that is my official recommendation, but, if you can get good odds on a -9.5 or -13.5, I would consider taking it. If not, I think this is a very safe pick, with an extremely high chance of success

Pittsburgh Steelers -1 vs. New Orleans Saints – 1 pm (Competing Picks)

Ernie Horn
Ernie Horn

Ernie Horn is a veteran newspaper writer with 25 years of experience. As a bettor, Ernie has exceeded 60% of his predictions over the past three years.

Coming off a short week, the New Orleans Saints visit a well-rested Pittsburgh Steelers squad in a match-up of two six-loss teams with wildly different expectations.

Despite the 3-6 mark, New Orleans is only one game out of first place in the moribund NFC South division. This marks the Saints’ second straight week battling an AFC North division foe, having lost to Baltimore 27-13 Monday night. In that game, the Saints yielded 188 yards and two rushing touchdowns, allowing the Ravens 4.7 yards per rush.

The Steelers—who have their worst record in nearly 40 years—are rebuilding this year. Star RB Najee Harris leads the team with 361 yards but averaging a career-low 3.3 yards per rush.

Pittsburgh’s rookie QB Kenny Pickett should have an opportunity to shine this week as New Orleans allows opposing QBs to complete more than 60 percent of their passes.

Expect a low-scoring offensive struggle this week in a cold, windy environment. Luck favors the home team with experience handling the weather conditions Sunday in a close, ugly contest.

Los Angeles Chargers +7.5 @ San Francisco 49ers – 8:20 pm

Ernie Horn
Ernie Horn

Ernie Horn is a veteran newspaper writer with 25 years of experience. As a bettor, Ernie has exceeded 60% of his predictions over the past three years.

When the Los Angeles Chargers visit the San Francisco 49ers Sunday night, both teams are looking for wins in order to keep pace with the division leaders.

The Chargers —one game out of the AFC West—features QB Justin Herbert, who is fifth-best in the NFL with 2,254 yards, completing over 66 percent of his passes. Herbert’s backfield teammate, Austin Ekeler, is a dual threat RB, rushing for 427 yards and six TDs while also catching a team-best 60 passes for 381 yards and four TDs.

San Francisco trails the surprising Seattle Seahawks by two games in the NFC West division. The 49ers have relied heavily on their NFL-best defense this season, a unit that is leading the league in fewest rushing yards and sixth-best in passing yards allowed in 2022.

To make a serious run at the playoffs, the 49ers traded for Christian McCaffrey in October. McCaffrey scored a trifecta of touchdowns last week by tossing, rushing, and catching a score. This week, McCaffrey will be joined by Deebo Samuels and seven other San Francisco players who are returning from injury after the bye week.

Expect this game to be closer than a touchdown throughout. While the 49ers should win this contest coming off their bye week, Herbert’s arm keeps the Chargers in this game until the end.

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Odds Assist Experts

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