Tennessee Titans @ Buffalo Bills – Week 2 MNF Picks & Betting Preview (2022-23 Season)

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Coming off a big Week 1 victory against the Los Angeles Rams last Thursday, The Bills should be feeling good and rested for this matchup at home against the Titans. They’ll be looking to build upon an outstanding offensive performance by Josh Allen and company, as well as the defensive excellence they got from Von Miller and the rest of the defense last week.

For the Titans, the story couldn’t be more different. They are trying to forget about their subpar performance last week, especially in the second half of the game, where they blew a 13-0 lead against the Giants and ended up losing 21-20 on a last-second missed field goal to a team that only managed to win four games last year.

The Titans need a bounce-back game, and they’ll need Derrick Henry to play a lot better than he did a week ago if they want to have any chance in this one.

  • Time: 7:15 ET
  • Location: Buffalo, New York
  • TV: ESPN
  • Weather: High of 71°F, Cloudy, Rain before the game but should be clear by kickoff

Tennessee Titans @ Buffalo Bills Spread Pick

There is no disputing that Derrick Henry is the engine that keeps the Titans offense going, but he failed to do that last week against the Giants as he ran for only one first down in the whole game. If the Titans are going to cover the spread, they are going to need their workhorse running back playing at the level we are used to.

The Titans don’t have A.J. Brown to rely on as a second option anymore, and Robert Woods and Treylon Burks didn’t do enough last week to give me much confidence that they can make up for his missing production. Kyle Phillips showed some promise as Tannehill’s go-to receiver in Week 1, but I’m still cautious on him giving the Titans enough offensive life to match the Bills electric offense.

Josh Allen ripped through the star-studded Rams defense last Thursday night, completing 26 of 31 passes for 297 yards and 3 touchdowns through the air as well as 56 yards and a touchdown on the ground. He is an MVP front runner already and I see no reason why he won’t rip through the Titans defense this week.

If Daniel Jones can lead the Giants to a one-point win over the Titans, Josh Allen and the Bills should be able to outscore the Titans by at least 10.

Spread Pick: BUFFALO BILLS (–10)

Titans @ Bills Total (Over/Under) Pick

The total points scored in this game is going to depend entirely on who controls the pace of this game. Will the Bills strike quickly and force the Titans to aggressively move the ball down the field, or will the Titans slow the pace down and control the time of possession?

If the Titans can keep the ball for long stretches of time and methodically move the ball down the field with Derrick Henry, we could see a low-scoring game.

Given the Bills impressive defense that kept the Rams to only 243 yards last week and won the time of possession 31:14 to 28:46, I would say it is more likely that the Bills dictate the pace of play in this game.

If the Bills get to decide the pace of this game, you better believe it is going to be a high-scoring game. Josh Allen has got a lot of weapons on this offense and if he can get into a good rhythm like he did last week, the Bills offense is going to force the Titans to try and keep up.

Regardless of whether the Titans can successfully keep pace with the Bills offense, the Bills are going to run up the score, I expect this game to easily exceed 48 points.

Spread Pick: OVER 47.5

Titans @ Bills Moneyline Pick

Despite the odds giving you good money on the Titans, I just don’t think it will happen and therefore won’t be betting it. The Bills are the better team and they are at home with 10 days of rest.

The Titans are coming off a devastating loss and now have to play a legit Super Bowl contender on the road, it doesn’t look good for them.

At the end of the day, I think the Bills will win by more than 10 points, meaning the best bet is to take the spread and stay away from the moneyline. However, if you are slightly more confident in the Titans beating the spread than I am, you might want to take the Bills moneyline here.

Moneyline Pick: Stay away, take the spread

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Kyler Wolff

Kyler Wolff is a sports writer with a passion for football and statistical analysis. He uses his knowledge of the game and ability to break down stats to make the best picks possible for our readers. He has previously worked for sportstips.com as a baseball betting picks writer and Diamondlobby.com as a Madden writer. See Kyler's posts.