Los Angeles Rams @ San Francisco 49ers – Week 4 MNF Picks & Betting Preview

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  • Time: 8:15 ET
  • Location: San Francisco, California
  • TV: ESPN
  • Weather: High of 76°, clear sky, no precipitation, winds of 9 mph

Believe it or not, but this will actually be the third matchup of these two teams so far this calendar year.

After a thrilling NFC Championship matchup in late January that resulted in a 20-17 win for the Rams over the 49ers on way to a Super Bowl win, this rivalry is as hot as it ever has been between these two teams.

They were both near the top of the league last year in terms of wins (Rams were 12-5 and the 49ers were 10-7) and came into the season as legitimate contenders.

Obviously, the circumstances of this game are quite a bit different than their last matchup. These teams are not the dominant presences that they were late last season.

Both teams have had their own unique struggles to start the 2022 season and are needing a dominant victory to reassert themselves as a top contender this year.

Rams at 49ers Moneyline Prediction

These two teams have been traditionally defense first the last few years and nothing has changed this year. They both rely on elite defenses to win games. What this game will come down to is how the offenses perform, despite struggles for both teams on that side of the ball early this year.

The 49ers are dealing with a season ending injury to Trey Lance, who they had hoped would have a Pat Mahomes-esque rise as their future franchise QB. His injury changes the tone of this season for the 49ers in terms of what they want out of their offense, but with Jimmy Garoppolo (the guy that led them to the NFC Championship game last year, by the way) as their backup, their expectations for this season won’t change too much. They are still a very good team.

The Rams got stunned early in their first game of the year against the Bills and lost 31-10 but have managed to win their last two games despite a fairly lackluster offensive showing.

Part of their poor offense has been due to the fact that they haven’t been able to get their running backs going at all. They have just 72 rushing yards per game and no RBs over 120 yards yet this season. It’s been quite pitiful, and it likely won’t get any better this week, as key offensive linemen, David Edwards and Brian Allen, are both out with injuries.

With that being the reality both teams must face, I think the 49ers are in a much better place to overcome their problems and get the W in front of their home fans.

Moneyline Pick: SAN FRANCISCO 49ERS

Rams (+1.5) at 49ers (-1.5) Spread Prediction

At home, coming off a tough loss in Denver after having to reshuffle their offense following Trey Lance’s injury, I expect the 49ers to be ready to bounce back.

Despite Jimmy G knowing the playbook very well, it’s not surprising that the San Francisco offense struggled to get anything going last week. They were beaten 34:30 to 25:30 in time of possession, after all, and had to completely switch how they played offense. Now after another week to right the ship, I think their offense should be much better.

As for the Rams' ability to stop the 49ers offense, they’ve given up 362 yards a game so far this season, which isn’t bad but is significantly more than their own offensive yards per game which sits at just 326. At the end of the day, this game will likely be determined by if the Rams can pick up their offensive production.

The Rams' one bright spot on offense has unsurprisingly been Cooper Kupp who has 280 receiving yards and 3 receiving touchdowns as well as a 20-yard touchdown run. This amounts to almost one-third of all the Rams offensive production. They will need someone else to step up, because as good as Kupp is, he is going to have a hard time making plays when he is double and triple-teamed by the 49ers secondary.

If a second offensive weapon is going to step up, it likely will have to be a receiver because of the key injuries on the Rams O-line that will likely slow down what is already a very bad rushing attack for the Rams. That leaves Allen Robinson as the obvious choice, and his 7 of 12 targets to catch ratio doesn’t give me much confidence in the Rams figuring things out in this one.

I’ll take the 49ers laying under a field goal.

Pick: SAN FRANCISCO 49ERS –1.5

Rams at 49ers (O/U 42.5) Total Prediction

These are two great defenses who have slightly underperformed so far this season. I think they will both turn it around at some point, but I don’t know if this week will be the week they do it.

Typically, when you’ve got defenses that include stars like Nick Bosa, Jalen Ramsey, Aaron Donald, Fred Warner, and Bobby Wagner up against struggling offenses, you’ve got a recipe for a low-scoring game, but the NFL is never really that simple.

These two teams are looking to assert themselves as the team to beat in the division and are somewhat desperate to get their offenses going. Expect them to come out firing in this one.

I expect a lot of passes, perhaps some high-tempo play calling, and even a few big turnovers or defensive touchdowns thrown in the mix.

I think we will see fireworks in this one. Lots of points!

Pick: OVER 42.5

Rams at 49ers MNF Quick Props

By Dave Rathmanner

Here are some prop picks I like for tonight:

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Kyler Wolff

Kyler Wolff is a sports writer with a passion for football and statistical analysis. He uses his knowledge of the game and ability to break down stats to make the best picks possible for our readers. He has previously worked for sportstips.com as a baseball betting picks writer and Diamondlobby.com as a Madden writer. See Kyler's posts.