Indianapolis Colts @ Denver Broncos – Week 5 TNF Picks & Betting Preview

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Both the Denver Broncos and Indianapolis Colts enter this game off of losses and struggling to find consistency through the first four games. The Broncos are 2-2 with wins at home over the 49ers and Texans, while the Colts are 1-2-1 with their only win coming two weeks ago over the Chiefs at home.

Here are our favorite picks for this Week 5 Thursday Night Football matchup between the Indianapolis Colts and Denver Broncos at Mile High.

  • Time: Thursday October 6, 2022, at 8:15 pm ET
  • TV: Amazon Prime
  • Game Location: Empower Field at Mile High in Denver, CO
  • Weather: Clear, light winds with temperatures in the low 60s

Pick 1: UNDER 42.5 Points (also worth a play on Alternate total Under 37.5 (+176) on FanDuel Sportsbook)

Both teams enter this one off a short week and with injuries on offense. 

Colts running back Jonathan Taylor will sit this one out with an ankle injury. 

Broncos quarterback Russell Wilson is also planning to play despite an injury to his throwing shoulder. The Broncos will also be without top running back Javonte Williams who was lost for the season due to an ACL and PCL tear.

In addition to the injuries that could slow both offenses down, both teams have been trending to the Under this year. The Colts are 4-0 to the Under and the Broncos are 3-1 to the Under for the season.

These are two of the three of lowest scoring offenses in the league, with Colts averaging just 14.3 points per game and the Broncos averaging only 16.5 points per game.

Smash Under 42.5 and consider the Alternate total of Under 37.5.

Pick 2: Russell Wilson UNDER 231.5 Pass Yards (-110) on FanDuel Sportsbook

Russell Wilson has struggled mightily to start the season, completing only 61% of passes. He will be facing off against a top ten Colts passing defense that is allowing only 207 passing yards per game.

Facing a tough defense with an injured shoulder is not an ideal combination, look for him to go under his passing yards prop Thursday night.

Pick 3: Melvin Gordon OVER 70.5 Rush/Receiving Yards (-115) at BetMGM

The Broncos should feature Melvin Gordon as the clear-cut number 1 back with the injury to Javonte Williams.

With Wilson banged up look for Gordon to get plenty of opportunities to touch the ball both on the ground and catching the ball from the backfield. He’s been averaging 47 yards per game in a complimentary role to start year, now that he is the go to back in Denver expect him to deliver and get over 70.5 yards combined rushing and receiving Thursday night.

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Rob O'Connor

Rob O’Connor is a veteran sports handicapper. He broke into the industry in 2002 and has continued to provide his clients with high quality sports handicapping advice ever since. He is currently a handicapper with Rob Veno Sports and prior to that ran his own sports handicapping service. Rob has been featured on ESPN Radio as well as on his hometown sports station WIP out of Philadelphia. Rob O'Connor handicaps the NFL, College Football, College Basketball, and Major League Baseball.