Companies on this page may compensate us if you sign up through our links. This doesn’t affect our opinions in any way. Must be 21+. Gambling Problem? Call 1-800-GAMBLER. See full disclosure.

NFL Week 6 & NCAAF Week 7 Best Bets & Picks

We had yet another profitable week last week, going 4-3 on our NFL and NCAAF best bets, bringing our overall record up to 20-16-2.

Let's see if we can keep it rolling with 7 picks for Week 6 of the NFL season and Week 7 of college football.

Be sure to compare the lines and odds before placing your bets to find the best deal currently available.

Want to get picks delivered straight to your inbox each week? Sign up for our weekly newsletter here.

NFL Week 6 & NCAAF Week 7 Best Bets

Illinois -21 vs. Purdue – 3:30 pm ET on FS1

Purdue’s four games against FBS competition have been an absolute disaster this year. They are 0-4 in those games, allowing 46 points per game, with the average margin of defeat being 35 points. They also have the fifth-worst defense of the Power 4 conference teams.

Illinois, on the other hand, has put together a strong start to the season, opening up 4-1, with their only loss coming on the road at Penn State.

Illinois is coming off a bye and has the rest advantage heading in to this game as well. Their defense has been especially strong, allowing less than 18 points per game against their four FBS opponents.

Look for them to score at will against the Purdue defense and get plenty of stops to cover the large number.

>> Use our College Football Odds Comparison Tool to find the best lines & odds

Offers from our partners

Right Arrow
None available for your state

USC +4.5 vs. Penn State – 3:30 pm ET on CBS

Penn State is heading across the country to take on a USC team with something to prove after a disappointing road loss to Minnesota last week.

Penn State has not traveled much this year, with only a quick trip to West Virginia to open the year. They have played four straight home games and have not looked all that impressive. They barely got back MAC opponent Bowling Green, and they have struggled offensively this year.

USC is the much more tested team, having played games against LSU, Michigan, Wisconsin, and Minnesota.

Look for USC to keep this one close and cover Saturday afternoon.

>> Use our College Football Odds Comparison Tool to find the best lines & odds

Pitt -3 vs. Cal – 3:30 pm ET on ESPN

This is another case where travel will most certainly catch up to Cal. This will be their third trip across the country in the last six weeks.

They also have to be very disappointed with blowing a 25-point second-half lead and losing to Miami at home by 1 last week.

Pitt continues to get better as they have gotten RB Rodney Hammond Jr. back from the ineligible list, and he will continue to integrate with the offense.

Pitt QB Eli Holstein has looked great this year, completing nearly 66% of his passes, with 15 touchdowns to just 3 interceptions.

Look for Pitt to win and cover this small number at home Saturday.

>> Use our College Football Odds Comparison Tool to find the best lines & odds

Kentucky -12.5 vs. Vanderbilt – 7:45 pm ET on SECN

Vanderbilt is coming off a historic upset of Alabama and will be primed for a letdown on Saturday night.

Kentucky already has one embarrassing home loss this year to South Carolina and with them coming off a bye week, they will not be overlooking this Vanderbilt team.

The Kentucky defense has played very well this year, giving up just 13.4 points per game, which is very impressive considering two of those games were against offensive powers Ole Miss and Georgia.

While Vanderbilt has the win against Alabama to hang their hats on, they have still been a very inconsistent team and struggle defensively. In their four games against FBS opponents, they are allowing 32 points per game.

Look for Kentucky to get enough scores and stops to win by at least 2 touchdowns at home Saturday night.

>> Use our College Football Odds Comparison Tool to find the best lines & odds

NCAAF PICK OF THE WEEK: UCLA +4 vs. Minnesota – 9 pm ET on BTN

This is a classic letdown spot for Minnesota. They are coming off a huge upset win over USC and now head across the country to play an underachieving UCLA team they may be overlooking.

Teams in the Big Ten have struggled with long travel this year, as it’s something they are not typically used to. This will be Minnesota’s first long trip of the year, with their only other road game coming against Michigan, who is close by.

The UCLA schedule has been grueling. They have played three consecutive ranked teams and lost all of those games. Look for them to finally catch their breath and get back on track Saturday, keeping this close against Minnesota.

>> Use our NFL Odds Comparison Tool to find the best lines & odds

Offers from our partners

Right Arrow
None available for your state

Jacksonville Jaguars +1.5 @ Chicago Bears – 9:30 am ET on NFLN (London)

The Bears have struggled on the road this year, going 0-2 and putting up just 14.5 points per game. While they may be considered the home team for scheduling purposes, this will definitely be treated as a road game for them.

The trip to London is much more familiar for the Jacksonville Jaguars, who play in London every year, than it is for the Bears.

The Jaguars got their first win of the year last week and look to build off of that.

The Bears three wins have come against teams that are a combined 3-11 on the year, so it’s not like they have been beating good teams.

I expect Jacksonville to pull the upset as a small underdog on Sunday.

>> Use our NFL Odds Comparison Tool to find the best lines & odds

NFL PICK OF THE WEEK: Denver Broncos +3 vs. Los Angeles Chargers – 4:05 pm ET on CBS

This is a great situation for the Broncos’ defense as they will be facing a less than 100% Chargers QB Justin Herbert, who remains limited in practice with an ankle injury.

That won’t bode well for the Chargers, as the Broncos’ defense ranks near the top of the league. An immobile QB will surely not help their cause.

Bo Nix and the Broncos have been playing better football, winning three straight games, with the offense averaging over 23 points a game during the winning streak.

The Broncos tend to play extremely well at home against the Chargers, winning 9 of the last 10 games between the teams in Denver. Look for them to cover the 3 and perhaps pull the outright upset on Sunday afternoon.

>> Use our NFL Odds Comparison Tool to find the best lines & odds