NFL Week 6 Picks – Sunday Best Bets

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We're nearing the halfway mark of the NFL season and we're getting a better idea of which teams are playoff contenders and which seem to be hoping for more losses to secure a top draft spot.

If you're looking to get in on the action for Week 6, we've got you covered with 5 picks from our team of experts, including 3 spread and 2 total bets.

Below you’ll find our picks for the best NFL bets to make on Sunday (10/15) for Week 6 of the 2023 NFL season. Remember, you can always compare NFL lines and odds by sportsbooks here.

Best NFL Week 6 Betting Picks

Baltimore Ravens -4 @ Tennessee Titans – 9:30 am ET (London game)

Picture of Rob O'Connor
Rob O'Connor

Rob O’Connor is a veteran sports handicapper. He broke into the industry in 2002 and has continued to provide high quality sports handicapping advice ever since.

The Ravens made the decision to travel to London on Monday following their 17-10 loss to the Steelers last week.

This is a good decision as it will give them more time to adjust to the time difference than the Tennessee Titans will have, who decided they would not travel over until Thursday after practice, making it a quick adjustment for them.

In addition to the travel advantage, the Ravens are simply the better team.

Their defense is allowing the 2nd fewest yards per game at 266.4 yards allowed. They are tied for 3rd in the league, allowing just 15 points per game.

That will spell trouble for a Tennessee offense that continues to struggle. They are scoring only 17.6 points per game on the year, ranking them towards the bottom at 26th in the league.

The Titans best offensive weapon Derek Henry will have trouble carrying the load against a Ravens run defense that is allowing just under 92 yards per game on the ground.

I trust Lamar Jackson and the Ravens offense to make enough plays and score enough points to cover the number against a Titans team that will struggle to score.

Lay the -4 with Baltimore.

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San Francisco 49ers -9.5 @ Cleveland Browns – 1 pm ET

Picture of Kyler Wolff
Kyler Wolff

Kyler Wolff is a sports writer with a passion for football & statistical analysis. He uses his knowledge of the game and ability to break down stats to make the best picks.

We don't know for sure if Deshaun Watson will play, but honestly, it shouldn't matter much. San Francisco has been so dominant on both sides of the ball and doesn't seem to be slowing down. They have not beat a team by less than 7 this season, and it shouldn't change this week, even against the Browns, who have very impressive defensive stats.

The Browns have allowed the fewest passing yards per game (125) and the fourth fewest yards rushing per game (71.8), but those numbers don't show the whole story. Three of their four games have been against division opponents, which tend to be more defense-driven, and they have been the beneficiary of some poor offensive execution by the Bengals and Titans.

Against the Browns last week, Lamar Jackson found the endzone 4 and the Browns’ offense only put up 3 points. In the 49ers' last game, they put up 42 points against what was supposed to be the best defense in the league and kept the Cowboys to only 10 points in an absolute rout of Dallas.

The 49ers have won their last 3 games by a total of 69 points, and they look unstoppable. Take them under 10 points in Cleveland.

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Chicago Bears +3 vs. Minnesota Vikings – 1 pm

Picture of Rob O'Connor
Rob O'Connor

Rob O’Connor is a veteran sports handicapper. He broke into the industry in 2002 and has continued to provide high quality sports handicapping advice ever since.

The Bears finally showed a semblance of both an offense and defense in a strong win at Washington last Thursday night 40-20. The Bears are in a good spot heading in to this one with a few extra days of rest and preparation.

The Vikings, meanwhile, are dealing with an injury to star WR Justin Jefferson who will miss at least the next 4 weeks after being placed on IR following the Vikings 27-20 loss at home to the Chiefs last week, which dropped the Vikings to 1-4 on the season.

The Bears are actually good against the run allowing under 100 yards per game, so that will put more pressure on the Vikings banged-up passing game.

The Bears defense finally held an opponent to under 25 points for the first time in nearly a season’s worth of games last week. They did so with the help of strong pressure on Sam Howell, who was sacked 5 times by the Bears defense.

Kirk Cousins is not known for his mobility, he has under 25 rush yards on the season and has been sacked 13 times in 5 games.

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Carolina Panthers @ Miami Dolphins OVER 47 – 1 pm ET

Picture of Kyler Wolff
Kyler Wolff

Kyler Wolff is a sports writer with a passion for football & statistical analysis. He uses his knowledge of the game and ability to break down stats to make the best picks.

I was burned last week by going with the over on a Dolphins game, but I'm confident I can get my revenge this week. It may be the definition of insanity, but I'm doing the same thing this week, and I hope to get a different outcome.

Last week, the Giants and Dolphins fell short of the total by just 1 point, with the last points being scored with more than half of the fourth quarter left, but the Giants' inept offense failed to punch it in after a long 13-play, 5-minute drive.

This week against the Panthers should be different.

Say what you will about the winless Panthers, but they definitely have scoring potential. Bryce Young is continuing to get better with experience and has been relying on the steady hands of Adam Thielen to create offensive momentum that has seen them score 64 points over the last three games. Their offense looks a lot more cohesive than the Giants' offense that scored just 16 points against the Dolphins' defense. I expect 20+ points by the Panthers.

As for the Dolphins, De'von Achane was placed on IR, but he's far from their only source of offense. Speed permeates through this offense from top to bottom, and they should have no problem putting up a similar number to what they scored last week against the Giants.

I've got the over in this one, and I think they'll actually get over the hump this week, unlike the disappointing result last week.

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New England Patriots @ Las Vegas Raiders UNDER 42 – 4:05 pm ET

Picture of Kyler Wolff
Kyler Wolff

Kyler Wolff is a sports writer with a passion for football & statistical analysis. He uses his knowledge of the game and ability to break down stats to make the best picks.

I thought about avoiding this game altogether because of the past trauma of last year's matchup between these two teams, where Jakobi Meyers inexplicably decided to throw the ball backward 20 yards and lost me my bet, which sent me on a months-long cold streak.

Now this season, Jakobi Meyers has switched teams, and I'm still reeling from what occurred one year ago, but I'm confident that I can get a good result this week. The bet is too good to give up on because of what happened last year.

This bet looks like a slam dunk. Neither of these teams has much potential to have a big offensive performance, and their recent play suggests that neither team will be able to get into an offensive rhythm and score consistently.

The Patriots are a good bet for going under total points scored, given their relatively good defense and their pathetic offense that has only scored 3 points in their last 2 games.

On the other side, you have the Raiders, who've only been in one game where the total exceeded 41 points, and that was against Josh Allen and the Bills. The Patriots are not the Bills; in fact, the Bills are third in the league in points scored per game, while the Patriots are dead last.

The Pats have been horrendous, and the Raiders aren't built to run up the score, so I feel very confident in this pick working out… but you never know with these 2 teams.

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Odds Assist Experts

The Odds Assist Experts consist of veteran handicappers with expertise in projections, finding favorable lines, and ultimately making winning picks.